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Factor D also known as complement factor D(CFD) or adipsin a protein which in humans is encoded by the CFD gene.[1] Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B.
[edit] Function
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.[1]
Alternative pathway. ( 4. Is factor D cleaving B to Bb and Ba)
Factor D is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis.[2]
[edit] Clinical significance
The level of Factor D is elevated in the obese, this elevation may be due to high activity or resistance but exact cause is not totally known.
[edit] References
[edit] External links
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Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21) |
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| Digestive enzymes |
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| Coagulation |
factors: Thrombin · Factor VIIa · Factor IXa · Factor Xa · Factor XIa · Factor XIIa · Kallikrein ( PSA, KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK12, KLK13, KLK14, KLK15)
fibrinolysis: Plasmin · Plasminogen activator ( Tissue plasminogen activator · Urinary plasminogen activator)
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| Complement system |
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| Other immune system |
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| Venombin |
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| Other |
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
